Article
A double amino-acid change in the HLA-A peptide-binding groove is associated with response to psychotropic treatment in patients with schizophrenia.
Translational psychiatry - 28 Jul 2015
Le Clerc S, Taing L, Fond G, Meary A, Llorca P-M, Blanc O, Beaune P, Rajagopal K, Jamain S, Tamouza R, Zagury J-F, Leboyer M
Abstract excerpt
The choice of an efficient psychotropic treatment for patients with schizophrenia is a key issue to improve prognosis and quality of life and to decrease the related burden and costs. As for other complex disorders, response to drugs in schizophrenia is highly heterogeneous and the underlying molecular mechanisms of this diversity are still poorly understood. In a carefully followed-up cohort of schizophrenic...
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