Article
Intravenously Administered Recombinant Human Type VII Collagen Derived from Chinese Hamster Ovary Cells Reverses the Disease Phenotype in Recessive Dystrophic Epidermolysis Bullosa Mice.
The Journal of investigative dermatology - 1 Dec 2015
Hou Yingping, Guey Lin T, Wu Timothy, Gao Robert, Cogan Jon, Wang Xinyi, Hong Elizabeth, Vivian Ning Weihuang, Keene Douglas, Liu Nan, Huang Yan, Kaftan Craig, Tangarone Bruce, Quinones-Garcia Igor, Uitto Jouni, Francone Omar L, Woodley David T, Chen Mei
Abstract excerpt
Recessive dystrophic epidermolysis bullosa (RDEB) is an inherited disorder characterized by skin fragility, blistering, and multiple skin wounds with no currently approved or consistently effective treatment. It is due to mutations in the gene encoding type VII collagen (C7). Using recombinant human C7 (rhC7) purified from human dermal fibroblasts (FB-rhC7), we showed previously that intravenously injected rhC7...
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