Article
Plants Possess a Cyclic Mitochondrial Metabolic Pathway similar to the Mammalian Metabolic Repair Mechanism Involving Malate Dehydrogenase and l-2-Hydroxyglutarate Dehydrogenase.
Plant & cell physiology - 1 Sept 2015
Hüdig Meike, Maier Alexander, Scherrers Isabell, Seidel Laura, Jansen Erwin E W, Mettler-Altmann Tabea, Engqvist Martin K M, Maurino Veronica G
Abstract excerpt
Enzymatic side reactions can give rise to the formation of wasteful and toxic products that are removed by metabolite repair pathways. In this work, we identify and characterize a mitochondrial metabolic repair mechanism in Arabidopsis thaliana involving malate dehydrogenase (mMDH) and l-2-hydroxyglutarate dehydrogenase (l-2HGDH). We analyze the kinetic properties of both A. thaliana mMDH isoforms, and show that...
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