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Article

Allelic Spectra of Risk SNPs Are Different for Environment/Lifestyle Dependent versus Independent Diseases.

PLoS genetics - 1 Jul 2015

Gorlov Ivan P, Gorlova Olga Y, Amos Christopher I

Abstract excerpt

Genome-wide association studies (GWAS) have generated sufficient data to assess the role of selection in shaping allelic diversity of disease-associated SNPs. Negative selection against disease risk variants is expected to reduce their frequencies making them overrepresented in the group of minor (<50%) alleles. Indeed, we found that the overall proportion of risk alleles was higher among alleles with frequency...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26201053
DOI: 10.1371/journal.pgen.1005371
PMCID: PMC4511800

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