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Article

Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance.

Journal of molecular medicine (Berlin, Germany) - 1 Dec 2015

Galimov Artur, Hartung Angelika, Trepp Roman, Mader Alexander, Flück Martin, Linke Axel, Blüher Matthias, Christ Emanuel, Krützfeldt Jan

Abstract excerpt

UNLABELLED: Replacement of growth hormone (GH) in patients suffering from GH deficiency (GHD) offers clinical benefits on body composition, exercise capacity, and skeletal integrity. However, GH replacement therapy (GHRT) is also associated with insulin resistance, but the mechanisms are incompletely understood. We demonstrate that in GH-deficient mice (growth hormone-releasing hormone receptor (Ghrhr)(lit/lit)),...

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Topics

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Share to Dwarfism, Pituitary
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human Growth Hormone

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Share to Muscle Fibers, Skeletal

Share to Receptors, Neuropeptide

Share to Receptors, Pituitary Hormone-Regulating Hormone

Source

Open in PubMed Open full text

Identifiers

PMID: 26199111
DOI: 10.1007/s00109-015-1322-y
PMCID: PMC4661224

Genes

IGF1
PTEN
FSTL1
SERPINH1
SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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