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Article

The chemokine CXCL6 restricts human trophoblast cell migration and invasion by suppressing MMP-2 activity in the first trimester

28 Jun 2013

Abstract excerpt

STUDY QUESTION: Can the chemokine CXCL6 affect trophoblast cell migration and invasion in human first-trimester placenta? SUMMARY ANSWER: Chemokine CXCL6 inhibits trophoblast cell migration and invasion by suppressing matrix metalloproteinase (MMP)-2 activity in human first-trimester placenta. WHAT IS KNOWN ALREADY: Several chemokines including CXCL8, CXCL12, CXCL14, CXCL16, CX3CL1, CCL14 and CCL4 can promote or...

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PMID: 23814098
DOI: 10.1093/humrep/det258

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