Article
Audibility, speech perception and processing of temporal cues in ribbon synaptic disorders due to OTOF mutations.
Hearing research - 1 Dec 2015
Santarelli Rosamaria, del Castillo Ignacio, Cama Elona, Scimemi Pietro, Starr Arnold
Abstract excerpt
Mutations in the OTOF gene encoding otoferlin result in a disrupted function of the ribbon synapses with impairment of the multivesicular glutamate release. Most affected subjects present with congenital hearing loss and abnormal auditory brainstem potentials associated with preserved cochlear hair cell activities (otoacoustic emissions, cochlear microphonics [CMs]). Transtympanic electrocochleography (ECochG)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.