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Article

Preemptive Bone Marrow Transplantation for FANCD1/BRCA2.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Oct 2015

Khan Nicholas E, Rosenberg Philip S, Lehmann Harold P, Alter Blanche P

Abstract excerpt

Children with biallelic mutations in FANCD1/BRCA2 are at uniquely high risks of leukemia and solid tumors. Preemptive bone marrow transplantation (PE-BMT) has been proposed to avoid the development of leukemia, but empirical study of PE-BMT is unlikely because of the rarity of these children and the unknown benefit of PE-BMT. We used survival analysis to estimate the risks of leukemia and the expected survival if...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26183081
DOI: 10.1016/j.bbmt.2015.07.006
PMCID: PMC4568159

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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