Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer.

World journal of gastroenterology - 7 Jul 2015

Proença Marcela Alcântara, de Oliveira Juliana Garcia, Cadamuro Aline Cristina Targa, Succi Maysa, Netinho João Gomes, Goloni-Bertolo Eny Maria, Pavarino Érika Cristina, Silva Ana Elizabete

Abstract excerpt

AIM: To evaluate the effect of promoter region polymorphisms of toll-like receptor (TLR)2-196 to -174del and TLR4-1607T/C (rs10759932) on mRNA and protein expression in tumor tissue and of TLR4+896A/G (rs4986790) on colorectal cancer (CRC) risk. METHODS: The TLR2-196 to -174del polymorphism was investigated using allele-specific polymerase chain reaction (PCR) and the TLR4-1607T/C and TLR4+896A/G by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chi-Square Distribution
Share to Colorectal Neoplasms
Share to Gene Expression Regulation, Neoplastic
Share to Odds Ratio
Share to Real-Time Polymerase Chain Reaction
Share to Reverse Transcriptase Polymerase Chain Reaction
Share to Toll-Like Receptor 2
Share to Toll-Like Receptor 4

Source

Open in PubMed Open full text

Identifiers

PMID: 26167073
DOI: 10.3748/wjg.v21.i25.7730
PMCID: PMC4491960

Genes

TLR2
TLR4
ACTB
GAPDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer.PMID 26167073Read ↗

Evaluation of the detection of Toll-like receptors (TLRs) in cancer development and progression in patients with colorectal cancer.Semantic proximity Read ↗

Functional polymorphisms of Toll-like receptors 2 and 4 alter the risk for colorectal carcinoma in Europeans.Semantic proximity Read ↗

Association of TLR2 and TLR4 polymorphisms with risk of cancer: a meta-analysis.Semantic proximity Read ↗

Investigation of TLR2 (-196 to -174del) and TLR9 (T-1486C) Gene Polymorphisms Association with Inflammatory Bowel Diseases.Semantic proximity Read ↗

The TLR4 gene polymorphisms and susceptibility to cancer: a systematic review and meta-analysis.Semantic proximity Read ↗

Role of toll-like receptor 4 in colorectal carcinogenesis: a meta-analysis.Semantic proximity Read ↗

Correlation between genetic polymorphisms within IL-1B and TLR4 genes and cancer risk in a Russian population: a case-control study.Semantic proximity Read ↗

Toll-Like Receptors (TLRs): Structure, Functions, Signaling, and Role of Their Polymorphisms in Colorectal Cancer Susceptibility.Semantic proximity Read ↗

-196 to -174del, rs4696480, rs3804099 polymorphisms of Toll-like receptor 2 gene impact the susceptibility of cancers: evidence from 37053 subjects.Semantic proximity Read ↗

Genetic association and functional implications of TLR4 rs1927914 polymorphism on colon cancer risk.Semantic proximity Read ↗

Expression and Polymorphism of Toll-Like Receptor 4 and Effect on NF-κB Mediated Inflammation in Colon Cancer PatientsSemantic proximity Read ↗

Potential role of Toll-like receptor 2 expression and polymorphisms in colon cancer susceptibility in the Saudi Arabian populationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.