Article
-295 T-to-C promoter region IL-16 gene polymorphism is associated with Whipple's disease.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Sept 2015
Biagi F, Schiepatti A, Badulli C, Sbarsi I, Trotta L, Feurle G E, Müller C, Moos V, Schneider T, Marth T, De Amici M, Martinetti M, Corazza G R
Abstract excerpt
Whipple's disease (WD) is a rare systemic condition caused, in genetically predisposed subjects, by Tropheryma whipplei, a common bacterium widespread in the environment. The relevance of genetic predisposition in WD is shown by the association with HLA alleles DRB1*13 and DQB1*06 and by the demonstration that, in patients with WD, the cytokine genetic profile is skewed toward a Th2 and Treg response. Since IL-16...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.