Article
Reanalysis of parabiosis of obesity mutants in the age of leptin.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 2015
Zeng Wenwen, Lu Yi-Hsueh, Lee Jonah, Friedman Jeffrey M
Abstract excerpt
In this study we set out to explain the differing effects of parabiosis with genetically diabetic (db) mice versus administration of recombinant leptin. Parabiosis of db mutant, which overexpress leptin, to wildtype (WT) or genetically obese (ob) mice has been reported to cause death by starvation, whereas leptin infusions do not produce lethality at any dose or mode of delivery tested. Leptin is not...
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