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Article

Icotinib might be effective for the treatment of leptomeningeal carcinomatosis in non-small cell lung cancer with sensitive EGFR mutations.

Lung cancer (Amsterdam, Netherlands) - 1 Sept 2015

Gong Lei, Xiong Ming, Huang Zhiyu, Miao Lulu, Fan Yun

Abstract excerpt

BACKGROUND: The incidence of leptomeningeal carcinomatosis (LMC) has increased in patients with metastatic non-small cell lung cancer (NSCLC). This study aimed to evaluate the effect of icotinib in the treatment of LMC. METHODS: Twenty-one NSCLC patients diagnosed with LMC and treated with icotinib were retrospectively reviewed. RESULTS: An exon 21 point mutation and an exon 19 deletion of EGFR were found in 10...

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Source

Identifiers

PMID: 26141219
DOI: 10.1016/j.lungcan.2015.06.001

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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