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The impact of Thr91 mutation on c-Src resistance to UM-164: molecular dynamics study revealed a new opportunity for drug design.

Molecular bioSystems - 30 May 2017

Ndagi Umar, Mhlongo Ndumiso N, Soliman Mahmoud E

Abstract excerpt

The emergence of a drug resistant non-receptor tyrosine kinase (c-Src) in triple-negative breast cancer (TNBC) remains a prime concern in relation to the burden of TNBC among people living with breast cancer and drug development. Thr91 mutation was found to induce a complete loss of protein conformation required for drug fitness. Herein, we provide the first account of the molecular impact of the Thr91 mutation...

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PMID: 28463369
DOI: 10.1039/c6mb00848h

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