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Article

DNA Methylation-Guided Prediction of Clinical Failure in High-Risk Prostate Cancer

18 Jun 2015

Abstract excerpt

BACKGROUND: Prostate cancer (PCa) is a very heterogeneous disease with respect to clinical outcome. This study explored differential DNA methylation in a priori selected genes to diagnose PCa and predict clinical failure (CF) in high-risk patients. METHODS: A quantitative multiplex, methylation-specific PCR assay was developed to assess promoter methylation of the APC, CCND2, GSTP1, PTGS2 and RARB genes in...

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PMID: 26086362
DOI: 10.1371/journal.pone.0130651

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