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Article

Alterations of the spindle checkpoint pathway in clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas.

International journal of cancer - 1 Dec 2015

Arai Eri, Gotoh Masahiro, Tian Ying, Sakamoto Hiromi, Ono Masaya, Matsuda Akio, Takahashi Yoriko, Miyata Sayaka, Totsuka Hirohiko, Chiku Suenori, Komiyama Motokiyo, Fujimoto Hiroyuki, Matsumoto Kenji, Yamada Tesshi, Yoshida Teruhiko, Kanai Yae

Abstract excerpt

CpG-island methylator phenotype (CIMP)-positive clear cell renal cell carcinomas (RCCs) are characterized by accumulation of DNA hypermethylation of CpG islands, clinicopathological aggressiveness and poor patient outcome. The aim of this study was to clarify the molecular pathways participating in CIMP-positive renal carcinogenesis. Genome (whole-exome and copy number), transcriptome and proteome...

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Source

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Identifiers

PMID: 26061684
DOI: 10.1002/ijc.29630
PMCID: PMC4755138

Genes

AURKA
AURKB
BUB1
CDC20
DNAH10
DNAH2
DNAH5
HAUS8
NEK2
SPC25

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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