Article
Prognostication of patients with clear cell renal cell carcinomas based on quantification of DNA methylation levels of CpG island methylator phenotype marker genes.
BMC cancer - 20 Oct 2014
Tian Ying, Arai Eri, Gotoh Masahiro, Komiyama Motokiyo, Fujimoto Hiroyuki, Kanai Yae
Abstract excerpt
BACKGROUND: The CpG island methylator phenotype (CIMP) of clear cell renal cell carcinomas (ccRCCs) is characterized by accumulation of DNA methylation at CpG islands and poorer patient outcome. The aim of this study was to establish criteria for prognostication of patients with ccRCCs using the ccRCC-specific CIMP marker genes. METHODS: DNA methylation levels at 299 CpG sites in the 14 CIMP marker genes were...
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