Article
Allostasis and Resilience of the Human Individual Metabolic Phenotype.
Journal of proteome research - 2 Jul 2015
Ghini Veronica, Saccenti Edoardo, Tenori Leonardo, Assfalg Michael, Luchinat Claudio
Abstract excerpt
The urine metabotype of 12 individuals was followed over a period of 8-10 years, which provided the longest longitudinal study of metabolic phenotypes to date. More than 2000 NMR metabolic profiles were analyzed. The majority of subjects have a stable metabotype. Subjects who were exposed to important pathophysiological stressful conditions had a significant metabotype drift. When the stress conditions ceased,...
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