Article
Response and toxicity prediction by MALDI-TOF-MS serum peptide profiling in patients with non-small cell lung cancer.
Proteomics. Clinical applications - 1 Jul 2016
Rovithi Maria, Lind Joline S W, Pham Thang V, Voortman Johannes, Knol Jaco C, Verheul Henk M W, Smit Egbert F, Jimenez Connie R
Abstract excerpt
PURPOSE: We validated a previously reported proteomic signature, associated with treatment outcome, in an independent cohort of patients with non-small cell lung cancer (NSCLC). A novel peptide signature was developed to predict toxicity. EXPERIMENTAL DESIGN: Using automated magnetic C18 bead-assisted serum peptide capture coupled to MALDI-TOF MS, we conducted serum peptide profiling of 50 NCSLC patients...
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