Article
Dystrophin hydrophobic regions in the pathogenesis of Duchenne and Becker muscular dystrophies.
Bosnian journal of basic medical sciences - 20 May 2015
Liang Yingyin, Chen Songlin, Zhu Jianzong, Zhou Xiangxue, Yang Chen, Yao Lu, Zhang Cheng
Abstract excerpt
The aim of our study was to determine the role of dystrophin hydrophobic regions in the pathogenesis of Duchenne (DMD) and Becker (BMD) muscular dystrophies, by the Kyte-Doolittle scale mean hydrophobicity profile and 3D molecular models. A total of 1038 cases diagnosed with DMD or BMD with the in-frame mutation were collected in our hospital and the Leiden DMD information database in the period 2002-2013....
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