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Article

Structural investigations of T854A mutation in EGFR and identification of novel inhibitors using structure activity relationships.

BMC genomics - 1 Jan 2015

Goyal Sukriti, Jamal Salma, Shanker Asheesh, Grover Abhinav

Abstract excerpt

BACKGROUND: The epidermal growth factor receptor (EGFR) is a member of the ErbB family that is involved in a number of processes responsible for cancer development and progression such as angiogenesis, apoptosis, cell proliferation and metastatic spread. Malfunction in activation of protein tyrosine kinases has been shown to result in uncontrolled cell growth. The EGFR TK domain has been identified as suitable...

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Identifiers

PMID: 26041145
DOI: 10.1186/1471-2164-16-S5-S8
PMCID: PMC4460657

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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