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Article

The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair.

Cellular signalling - 1 Sept 2015

Balogh Andrea, Shimizu Yoshibumi, Lee Sue Chin, Norman Derek D, Gangwar Ruchika, Bavaria Mitul, Moon ChangSuk, Shukla Pradeep, Rao Radakrishna, Ray Ramesh, Naren Anjaparavanda P, Banerjee Souvik, Banerje Souvik, Miller Duane D, Balazs Louisa, Pelus Louis, Tigyi Gabor

Abstract excerpt

In this study we characterized the effects of radiation injury on the expression and function of the autotaxin (ATX)-LPA2 GPCR axis. In IEC-6 crypt cells and jejunum enteroids quantitative RT-PCR showed a time- and dose-dependent upregulation of lpa2 in response to γ-irradiation that was abolished by mutation of the NF-κB site in the lpa2 promoter or by inhibition of ATM/ATR kinases with CGK-733, suggesting that...

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Identifiers

PMID: 26027517
DOI: 10.1016/j.cellsig.2015.05.015
PMCID: PMC4514920

Genes

LPA
ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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