Article
[Evaluation of the antiviral therapy for chronic hepatitis C in patients unresponsive to previous treatment with regard to the interleukin-28B genotypes].
Voprosy virusologii - 1 Jan 2015
Fazylov V Ch, Tkacheva S V, Manapova E R, Jakupova F M
Abstract excerpt
The identification of the single nucleotide polymorphisms (SNP) at rs8099917 and rs12979860 loci of IL-28B gene is presently necessary for patients with the genotype HCV-1 to predict sustained viral response (SVR) in case of combined antiviral therapy with interferon and ribavirin. In addition to the implementation of the antiviral activity of IFN-α, interleukin-1β (IL-1β) and interferon-gamma (IFN-γ) are...
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