Physical exercise counteracts genetic susceptibility to depression.

doi:10.1159/000381350

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Article

Physical exercise counteracts genetic susceptibility to depression.

Neuropsychobiology - 1 Jan 2015

Haslacher Helmuth, Michlmayr Matthias, Batmyagmar Delgerdalai, Perkmann Thomas, Ponocny-Seliger Elisabeth, Scheichenberger Vanessa, Pilger Alexander, Dal-Bianco Peter, Lehrner Johann, Pezawas Lukas, Wagner Oswald, Winker Robert

Abstract excerpt

BACKGROUND/AIMS: Depression is a highly prevalent disorder in elderly individuals. A genetic variant (rs6265) of the brain-derived neurotrophic factor (BDNF) impacting on emotion processing is known to increase the risk for depression. We aim to investigate whether intensive endurance sports might attenuate this genetic susceptibility in a cohort of elderly marathon athletes. METHODS: Fifty-five athletes and 58...

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PMID: 25998702
DOI: 10.1159/000381350

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BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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