Article
A Chromosome 13 locus is associated with male-specific mortality in mice.
Aging clinical and experimental research - 1 Feb 2016
Gyekis Joseph P, Lang Dean H, Vandenbergh David J, Gerhard Glenn S, Griffith James W, Dodds Jeffery W, Shihabi Zakaria K, Tilley Mera K, Blizard David A
Abstract excerpt
BACKGROUND AND AIM: Mortality is a highly complex trait influenced by a wide array of genetic factors. METHODS: We examined a population of 1200 mice that were F2 generation offspring of a 4-way reciprocal cross between C57BL6/J and DBA2/J strains. Animals were sacrificed at age 200, 500, or 800 days and genotyped at 96 markers. The 800 days old cohort, which were the survivors of a much larger breeding group,...
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