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Article

Novel Human Cytomegalovirus Viral Chemokines, vCXCL-1s, Display Functional Selectivity for Neutrophil Signaling and Function.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2015

Heo Jinho, Dogra Pranay, Masi Tom J, Pitt Elisabeth A, de Kruijf Petra, Smit Martine J, Sparer Tim E

Abstract excerpt

Human CMV (HCMV) uses members of the hematopoietic system including neutrophils for dissemination throughout the body. HCMV encodes a viral chemokine, vCXCL-1, that is postulated to attract neutrophils for dissemination within the host. The gene encoding vCXCL-1, UL146, is one of the most variable genes in the HCMV genome. Why HCMV has evolved this hypervariability and how this affects the virus' dissemination...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25987741
DOI: 10.4049/jimmunol.1400291
PMCID: PMC4475499

Genes

CXCR1
CXCR2
CCL22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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