Article
Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis.
International journal of epidemiology - 1 Dec 2016
Nüesch Eveline, Dale Caroline, Palmer Tom M, White Jon, Keating Brendan J, van Iperen Erik Pa, Goel Anuj, Padmanabhan Sandosh, Asselbergs Folkert W, Verschuren W M, Wijmenga C, Van der Schouw Y T, Onland-Moret N C, Lange Leslie A, Hovingh G K, Sivapalaratnam Suthesh, Morris Richard W, Whincup Peter H, Wannamethe Goya S, Gaunt Tom R, Ebrahim Shah, Steel Laura, Nair Nikhil, Reiner Alexander P, Kooperberg Charles, Wilson James F, Bolton Jennifer L, McLachlan Stela, Price Jacqueline F, Strachan Mark Wj, Robertson Christine M, Kleber Marcus E, Delgado Graciela, März Winfried, Melander Olle, Dominiczak Anna F, Farrall Martin, Watkins Hugh, Leusink Maarten, Maitland-van der Zee Anke H, de Groot Mark Ch, Dudbridge Frank, Hingorani Aroon, Ben-Shlomo Yoav, Lawlor Debbie A, Amuzu A, Caufield M, Cavadino A, Cooper J, Davies T L, Drenos F, Engmann J, Finan C, Giambartolomei C, Hardy R, Humphries S E, Hypponen E, Kivimaki M, Kuh D, Kumari M, Ong K, Plagnol V, Power C, Richards M, Shah S, Shah T, Sofat R, Talmud P J, Wareham N, Warren H, Whittaker J C, Wong A, Zabaneh D, Davey Smith George, Wells Jonathan C, Leon David A, Holmes Michael V, Casas Juan P
Abstract excerpt
Background: We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis. Methods: We developed an allele score based on 69 single nucleotide polymorphisms (SNPs) associated with adult height, identified by the IBCCardioChip, and used it for IV analysis against...
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