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Article

Delayed enrichment for c-kit and inducing cardiac differentiation attenuated protective effects of BMSCs' transplantation in pig model of acute myocardial ischemia.

Cardiovascular therapeutics - 1 Aug 2015

Zhang Guang-Wei, Gu Tian-Xiang, Guan Xiao-Yu, Sun Xue-Jun, Jiang Da-Qing, Tang Rui, Qi Xun, Li Xue-Yuan

Abstract excerpt

OBJECTIVE: To investigate the effects of immature cardiomyocytes differentiated from c-kit(+) bone marrow mesenchymal stem cells (BMSCs) against acute myocardial infarction (AMI). METHODS: Miniswine passage 8 BMSCs were enriched for c-kit and induced by 5 μM 5-azacytidine (AZA) for 14 days, and a second enrichment for the dihydropyridine receptor subunit α2δ1 was performed (enriched BMSCs). Thereafter, enriched...

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PMID: 25959676
DOI: 10.1111/1755-5922.12131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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