Article
MicroRNAs and Cardiac Regeneration.
Circulation research - 8 May 2015
Hodgkinson Conrad P, Kang Martin H, Dal-Pra Sophie, Mirotsou Maria, Dzau Victor J
Abstract excerpt
The human heart has a limited capacity to regenerate lost or damaged cardiomyocytes after cardiac insult. Instead, myocardial injury is characterized by extensive cardiac remodeling by fibroblasts, resulting in the eventual deterioration of cardiac structure and function. Cardiac function would be improved if these fibroblasts could be converted into cardiomyocytes. MicroRNAs (miRNAs), small noncoding RNAs that...
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