Article
Cytokine gene polymorphisms in obstructive sleep apnoea/hypopnoea syndrome.
Sleep medicine - 1 Jun 2015
Bielicki P, MacLeod A K, Douglas N J, Riha R L
Abstract excerpt
OBJECTIVE: The pro-inflammatory cytokines, TNF-α, IL-6, and IL-8 are elevated in obstructive sleep apnoea/hypopnoea syndrome (OSAHS). Cytokine gene interactions are complex and haplotype analysis may be more informative. We hypothesized that the effects of TNF-α in OSAHS might be due to linkage disequilibrium of the TNF-α (-308A) single nucleotide polymorphism (SNP) with other polymorphisms within the TNF-α gene,...
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