Article
IL-18, TNF, and IFN-γ alleles and genotypes are associated with susceptibility to chronic hepatitis B infection and severity of liver injury.
Journal of medical virology - 1 Oct 2015
Ferreira Sandro da Costa, Chachá Silvana Gama Florêncio, Souza Fernanda Fernandes, Teixeira Andreza Corrêa, Santana Rodrigo de Carvalho, Deghaide Neifi Hassan Saloun, Rodrigues Sandra, Marano Leonardo Arduíno, Mendes-Junior Celso Teixeira, Zucoloto Sérgio, Donadi Eduardo Antônio, Martinelli Ana de Lourdes Candolo
Abstract excerpt
This study evaluated the association of polymorphisms in the IL-18 (-607C/A and -137C/G), IFNγ (+874 A/T), and TNF (-238 A/G and -308 A/G) genes with susceptibility to HBV infection and severity of liver injury. A total of 259 chronic HBV-infected patients followed at the University Hospital, Faculty of Medicine of Ribeirão Preto, São Paulo, Brazil, and 202 healthy individuals were studied. Four Single Nucleotide...
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