Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults.

doi:10.1126/scitranslmed.aaa2373

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Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults.

Science translational medicine - 6 May 2015

Ogwang Caroline, Kimani Domtila, Edwards Nick J, Roberts Rachel, Mwacharo Jedidah, Bowyer Georgina, Bliss Carly, Hodgson Susanne H, Njuguna Patricia, Viebig Nicola K, Nicosia Alfredo, Gitau Evelyn, Douglas Sandy, Illingworth Joe, Marsh Kevin, Lawrie Alison, Imoukhuede Egeruan B, Ewer Katie, Urban Britta C, Hill Adrian V S, Bejon Philip

Abstract excerpt

Protective immunity to the liver stage of the malaria parasite can be conferred by vaccine-induced T cells, but no subunit vaccination approach based on cellular immunity has shown efficacy in field studies. We randomly allocated 121 healthy adult male volunteers in Kilifi, Kenya, to vaccination with the recombinant viral vectors chimpanzee adenovirus 63 (ChAd63) and modified vaccinia Ankara (MVA), both encoding...

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PMID: 25947165
DOI: 10.1126/scitranslmed.aaa2373
PMCID: PMC4687051

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