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Article

DanHong injection dose-dependently varies amino acid metabolites and metabolic pathways in the treatment of rats with cerebral ischemia.

Acta pharmacologica Sinica - 1 Jun 2015

Guo Zhi-li, Zhu Yan, Su Xiao-tao, Liu Jun, Yang Qian-xu, Nan Jing-yi, Zhao Bu-chang, Zhang Ying-ying, Yu Ya-nan, Li Bing, Xiao Hong-bin, Wang Zhong

Abstract excerpt

AIM: To determine how the relative amino acid contents and metabolic pathways regulate the pharmacological phenotypes in rats with cerebral ischemia after treatment with varying doses of DanHong injection (DHI). METHODS: Adult male rats underwent middle cerebral artery occlusion (MCAO), and were injected with DHI (DH-1: 1 mL/kg; DH-2: 2.5 mL/kg; DH-3: 5 mL/kg, and DH-4: 10 mL/kg, iv) daily for 3 d. The...

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Identifiers

PMID: 25937632
DOI: 10.1038/aps.2014.167
PMCID: PMC4594181

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