Article
Right ventricular nitric oxide signaling in an ovine model of congenital heart disease: a preserved fetal phenotype.
American journal of physiology. Heart and circulatory physiology - 1 Jul 2015
Kameny Rebecca Johnson, He Youping, Morris Catherine, Sun Christine, Johengen Michael, Gong Wenhui, Raff Gary W, Datar Sanjeev A, Oishi Peter E, Fineman Jeffrey R
Abstract excerpt
We recently reported superior right ventricle (RV) performance in response to acute afterload challenge in lambs with a model of congenital heart disease with chronic left-to-right cardiac shunts. Compared with control animals, shunt lambs demonstrated increased contractility because of an enhanced Anrep effect (the slow increase in contractility following myocyte stretch). This advantageous physiological...
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