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Article

XPD, APE1, and MUTYH polymorphisms increase head and neck cancer risk: effect of gene-gene and gene-environment interactions.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Sept 2015

Das Sambuddha, Bhowmik Aditi, Bhattacharjee Abhinandan, Choudhury Biswadeep, Naiding Momota, Laskar Agniv Kr, Ghosh Sankar Kumar, Choudhury Yashmin

Abstract excerpt

In the present study, we investigated the effect of the DNA repair gene polymorphisms XPD Asp312Asn (G>A), APE1 Asp148Glu (T>G), and MUTYH Tyr165Cys (G>A) on the risk for head and neck cancer (HNC) in association with tobacco use in a population of Northeast India. The study subjects comprised of 80 HNC patients and 92 healthy controls. Genotyping was performed using amplification refractory mutation system-PCR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25916209
DOI: 10.1007/s13277-015-3472-5

Genes

MUTYH

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