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Article

The role of apolipoprotein E episilon (ε)-4 allele on outcome following traumatic brain injury: A systematic review.

Brain injury - 1 Jan 2015

Lawrence David W, Comper Paul, Hutchison Michael G, Sharma Bhanu

Abstract excerpt

BACKGROUND: The apolipoprotein E gene (APOE) has emerged as a candidate for prognosticating traumatic brain injury (TBI) recovery, with APOEε4 identified as a susceptibility marker for poor outcome, despite large discrepancy in its reported influence post-TBI. METHODS: A systematic review was conducted, including all primary articles investigating the role of APOEε4 on TBI outcome. A total of 65 studies were...

Topics

Aged
Aged, 80 and over
Alleles
Apolipoprotein E4
Brain Injuries
Female
Genotype
Humans
Male
Prognosis
Treatment Outcome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25915580
DOI: 10.3109/02699052.2015.1005131

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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