Article
Genome sequencing of the Trichoderma reesei QM9136 mutant identifies a truncation of the transcriptional regulator XYR1 as the cause for its cellulase-negative phenotype.
BMC genomics - 20 Apr 2015
Lichius Alexander, Bidard Frédérique, Buchholz Franziska, Le Crom Stéphane, Martin Joel, Schackwitz Wendy, Austerlitz Tina, Grigoriev Igor V, Baker Scott E, Margeot Antoine, Seiboth Bernhard, Kubicek Christian P
Abstract excerpt
BACKGROUND: Trichoderma reesei is the main industrial source of cellulases and hemicellulases required for the hydrolysis of biomass to simple sugars, which can then be used in the production of biofuels and biorefineries. The highly productive strains in use today were generated by classical mutagenesis. As byproducts of this procedure, mutants were generated that turned out to be unable to produce cellulases....
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