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Article

Single Mutation in Transcriptional Activator Xyr1 Enhances Cellulase and Xylanase Production in Trichoderma reesei on Glucose.

Journal of agricultural and food chemistry - 9 Aug 2023

Lv Dongmei, Zhang Weixin, Meng Xiangfeng, Liu Weifeng

Abstract excerpt

To achieve cost-effective production of lignocellulolytic enzymes for biorefinery processes, engineering transcription factors represents a powerful strategy to boost cellulase and xylanase in Trichoderma reesei. In this study, a novel mutation (R434L) in xylanase regulator 1 (Xyr1) was identified based on the yeast one-hybrid screening system. The point mutation was located in the middle homology region of Xyr1...

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Identifiers

PMID: 37523749
DOI: 10.1021/acs.jafc.3c03466

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