Article
Predicting sudden cardiac death using common genetic risk variants for coronary artery disease.
European heart journal - 7 Jul 2015
Hernesniemi Jussi A, Lyytikäinen Leo-Pekka, Oksala Niku, Seppälä Ilkka, Kleber Marcus E, Mononen Nina, März Winfried, Mikkelsson Jussi, Pessi Tanja, Louhelainen Anne-Mari, Martiskainen Mika, Nikus Kjell, Klopp Norman, Waldenberger Melanie, Illig Thomas, Kähönen Mika, Laaksonen Reijo, Karhunen Pekka J, Lehtimäki Terho
Abstract excerpt
AIMS: Genome-wide association studies (GWAS) have identified many variants associating with an increased risk of coronary artery disease (CAD). We studied the possible association between these variants and the risk of sudden cardiac death (SCD). METHODS AND RESULTS: A weighted genetic risk score (GRSCAD) was formed from variants most strongly associating with CAD identified by the CARDIoGRAMplusC4D Consortium...
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