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Article

Multi-platform profiling of over 2000 sarcomas: identification of biomarkers and novel therapeutic targets.

Oncotarget - 20 May 2015

Movva Sujana, Wen Wenhsiang, Chen Wangjuh, Millis Sherri Z, Gatalica Zoran, Reddy Sandeep, von Mehren Margaret, Van Tine Brian A

Abstract excerpt

BACKGROUND: Drug development in sarcoma has been hampered by the rarity and heterogeneity of the disease and lack of predictive biomarkers to therapies. We assessed protein expression and gene alterations in a large number of bone and soft tissue sarcomas in order to categorize the molecular alterations, identify predictive biomarkers and discover new therapeutic targets. METHODS: Data from sarcoma specimens...

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Topics

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Share to Biomarkers, Tumor
Share to ALK gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MGMT gene

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Share to In Situ Hybridization, Fluorescence

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Source

Open in PubMed Open full text

Identifiers

PMID: 25906748
DOI: 10.18632/oncotarget.3498
PMCID: PMC4494935

Genes

ALK
BRCA2
EGFR
MGMT
PTEN
SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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