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Article

Methadone use in a male with the FMRI premutation and FXTAS.

American journal of medical genetics. Part A - 1 Jun 2015

Muzar Zukhrofi, Lozano Reymundo, Schneider Andrea, Adams Patrick E, Faradz Sultana M H, Tassone Flora, Hagerman Randi J

Abstract excerpt

The fragile X-associated tremor ataxia syndrome (FXTAS) is caused by the premutation in FMR1 gene. Recent reports of environmental toxins appear to worsen the progression of FXTAS. Here we present a case of male adult with FXTAS and a long history of methadone use. The patient shows a faster progression in both symptoms of disease and MRI changes compared to what is typically seen in FXTAS. There has been no...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25900641
DOI: 10.1002/ajmg.a.37030
PMCID: PMC4845901

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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