Article
The role of the SCN5A-encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders.
Neurogastroenterology and motility - 1 Jul 2015
Verstraelen T E, Ter Bekke R M A, Volders P G A, Masclee A A M, Kruimel J W
Abstract excerpt
BACKGROUND: Gastrointestinal functional and motility disorders, like irritable bowel syndrome (IBS), have a high prevalence in the Western population and cause significant morbidity and loss of quality of life leading to considerable costs for health care. A decade ago, it has been demonstrated that interstitial cells of Cajal and intestinal smooth muscle cells, cells important for gastrointestinal motility,...
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