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Structural and functional annotation of PR/SET Domain (PRDM) protein family: In-silico study elaborating role of PRDM12 mutation in congenital insensitivity to pain.

Computational biology and chemistry - 1 Dec 2020

Mehmood Sarmad, Dad Rubina, Ahmad Arsalan, Ullah Muhammad Ikram, John Peter, Ali Amjad, Hubner Christian A, Mohyuddin Aisha, Hassan Muhammad Jawad

Abstract excerpt

Congenital insensitivity to pain (CIP), classified as a type of hereditary sensory and autonomic neuropathies, is a rare disease in which the affected individuals fail to perceive sensation of pain. One of the PR/SET Domain Proteins, PRDM12, has been identified in recent past as a candidate gene for congenital insensitivity to pain. In the present study, we performed whole exome sequencing in a Pakistani family...

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PMID: 33010785
DOI: 10.1016/j.compbiolchem.2020.107382

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