Article
Novel mutations on the ace-1 gene of the malaria vector Anopheles albimanus provide evidence for balancing selection in an area of high insecticide resistance in Peru.
Malaria journal - 14 Feb 2015
Liebman Kelly A, Pinto Jesus, Valle Jorge, Palomino Miriam, Vizcaino Lucrecia, Brogdon William, Lenhart Audrey
Abstract excerpt
BACKGROUND: Resistance to multiple classes of insecticides has been detected in the malaria vector Anopheles albimanus in northwest Peru. Acetylcholinesterase (AChE) insensitivity has previously been associated with resistance to organophosphate (OP) and carbamate (CA) insecticides in arthropods. A single point mutation on the ace-1 gene (G119S) associated with resistance to OPs and CAs has been described...
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