Article
In vivo and in vitro characterization of a Plasmodium liver stage-specific promoter.
PloS one - 1 Jan 2015
De Niz Mariana, Helm Susanne, Horstmann Sebastian, Annoura Takeshi, Del Portillo Hernando A, Khan Shahid M, Heussler Volker T
Abstract excerpt
Little is known about stage-specific gene regulation in Plasmodium parasites, in particular the liver stage of development. We have previously described in the Plasmodium berghei rodent model, a liver stage-specific (lisp2) gene promoter region, in vitro. Using a dual luminescence system, we now confirm the stage specificity of this promoter region also in vivo. Furthermore, by substitution and deletion analyses...
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