Article

Progesterone is an Inducement of Heritable Pulmonary Arterial Hypertension with BMPR2 Mutation

2023-04-22

Abstract excerpt

<h4>Background</h4> Bone morphogenetic protein type II receptor (BMPR2) gene mutation accounts for 80% of patients with heritable pulmonary artery hypertension (HPAH), and female mutation carriers have significantly higher penetrance rate than males. The inducement of HPAH penetrance and the mechanism of sex differential penetrance are still elusive. <h4>Methods</h4> We infected or transfected pulmonary artery s...

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Literature Corpus work: 195b21ad-7423-54b0-92c6-f737d24ea71a
DOI: 10.1101/2023.04.21.537897

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