Article
Overall response to first-line tyrosine kinase inhibitor and second-line chemotherapy is predictive of survival outcome in epidermal growth factor receptor-mutated adenocarcinoma.
Chemotherapy - 1 Jan 2014
Kuo Scott Chih-Hsi, Hsu Ping-Chih, Chen Chih-Hung, Yu Chih-Teng, Wang Chih-Liang, Chung Fu-Tsai, Lin Shu-Min, Lo Yu-Lun, Chen Tse-Ching, Liu Chien-Ying, Yang Cheng-Ta
Abstract excerpt
BACKGROUND: First-line epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are effective for the treatment of lung adenocarcinoma with an EGFR-sensitizing mutation, but resistance is inevitable. Chemotherapy is widely used in the second-line setting. The outcome following this treatment scheme has not been thoroughly evaluated. METHODS: From 2007 to 2011, consecutive patients with mutated...
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