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Article

Multiple resistant factors in lung cancer with primary resistance to EGFR-TK inhibitors confer poor survival.

Lung cancer (Amsterdam, Netherlands) - 1 May 2015

Kim Go Woon, Song Joon Seon, Choi Chang-Min, Rho Jin Kyung, Kim Sun Ye, Jang Se Jin, Park Young Soo, Chun Sung-Min, Kim Woo Sung, Lee Jung-Shin, Kim Sang-We, Lee Dae Ho, Lee Jae Cheol

Abstract excerpt

OBJECTIVES: EGFR activating mutations have been recognized as the most important predictor of response to EGFR-tyrosine kinase inhibitors (EGFR-TKIs). However, 20-30% of patients harboring EGFR activating mutations show a poor response requiring investigation for underlying mechanisms. MATERIALS AND METHODS: Characteristics of 541 patients with lung cancer harboring EGFR activating mutations were analyzed to...

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Source

Identifiers

PMID: 25724261
DOI: 10.1016/j.lungcan.2015.01.023

Genes

EGFR
AXL
MET
PTEN

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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