Article
Resistin and interleukin-6 exhibit racially-disparate expression in breast cancer patients, display molecular association and promote growth and aggressiveness of tumor cells through STAT3 activation.
Oncotarget - 10 May 2015
Deshmukh Sachin K, Srivastava Sanjeev K, Bhardwaj Arun, Singh Ajay P, Tyagi Nikhil, Marimuthu Saravanakumar, Dyess Donna L, Dal Zotto Valeria, Carter James E, Singh Seema
Abstract excerpt
African-American (AA) women with breast cancer (BC) are diagnosed with more aggressive disease, have higher risk of recurrence and poorer prognosis as compared to Caucasian American (CA) women. Therefore, it is imperative to define the factors associated with such disparities to reduce the unequal burden of cancer. Emerging data suggest that inherent differences exist in the tumor microenvironment of AA and CA BC...
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