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Article

Transcriptional regulation of tenascin‐ W by TGF ‐beta signaling in the bone metastatic niche of breast cancer cells

13 Apr 2015

Abstract excerpt

Tenascin-W is a matricellular protein with a dynamically changing expression pattern in development and disease. In adults, tenascin-W is mostly restricted to stem cell niches, and is also expressed in the stroma of solid cancers. Here, we analyzed its expression in the bone microenvironment of breast cancer metastasis. Osteoblasts were isolated from tumor-free or tumor-bearing bones of mice injected with...

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PMID: 25868708
DOI: 10.1002/ijc.29565

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