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Autophagy potentially protects against 2,3,7,8-tetrachlorodibenzo-p-Dioxin induced apoptosis in SH-SY5Y cells.

Environmental toxicology - 1 Sept 2016

Zhao Jianmei, Tang Cuiying, Nie Xiaoke, Xi Hanqing, Jiang Shengyang, Jiang Junkang, Liu Suyi, Liu Xipeng, Liang Lingwei, Wan Chunhua, Yang Jianbin

Abstract excerpt

The environmental toxicant TCDD may elicit cytotoxic effects by inducing reactive oxygen species (ROS) generation. Autophagy is one of the first lines of defense against oxidative stress damage. Herein, we investigated whether autophagy played a regulatory role in TCDD-induced neurotoxicity. Here, we showed that TCDD exposure caused marked autophagy in SH-SY5Y cells, whose dose range was close to that inducing...

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PMID: 25865073
DOI: 10.1002/tox.22116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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